abstract：OBJECTIVE:Glucosamine is commonly used for the treatment of osteoarthritis, and its use is increasing in the general population. The Canadian Multicentre Osteoporosis Study (CaMos) provided an opportunity to examine the prevalence of glucosamine use across age and gender groups, and to assess the factors associated wit...

journal_title：Osteoarthritis and cartilage

authors： Hopman WM,Towheed TE,Gao Y,Berger C,Joseph L,Vik SA,Hanley DA,Carran J,Anastassiades T

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To examine whether urine concentrations of type II collagen neoepitope (uTIINE) distinguish subjects with progressive radiographic and/or symptomatic knee osteoarthritis (OA) from those with stable disease. METHODS:Subjects were 120 obese middle-aged women with unilateral knee OA who participated in a 30-mon...

journal_title：Osteoarthritis and cartilage

authors： Hellio Le Graverand MP,Brandt KD,Mazzuca SA,Katz BP,Buck R,Lane KA,Pickering E,Nemirovskiy OV,Sunyer T,Welsch DJ

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:Pain is the most common symptom in knee osteoarthritis (OA), a leading cause of chronic disability, and a major source of the disability attributable to OA in general. Pain severity in knee OA is variable, ranging from barely perceptible to immobilizing. The knee lesions that contribute to pain severity ha...

journal_title：Osteoarthritis and cartilage

authors： Torres L,Dunlop DD,Peterfy C,Guermazi A,Prasad P,Hayes KW,Song J,Cahue S,Chang A,Marshall M,Sharma L

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Chondrocyte death, a notable feature of osteoarthritis, may play a role in the initiation of cartilage degeneration. The present study was aimed at uncovering the nature and involvement of cell death in the initiation of cartilage degeneration induced by mechanical trauma. METHODS:Articular cartilage discs o...

journal_title：Osteoarthritis and cartilage

authors： Huser CA,Peacock M,Davies ME

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:We describe a technique to axially compress a sheep knee joint in an MRI scanner and measure articular cartilage deformation. As an initial application, tibial articular cartilage deformation patterns after 2 h of static loading before and after medial meniscectomy are compared. METHODS:Precision was establi...

journal_title：Osteoarthritis and cartilage

authors： Song Y,Greve JM,Carter DR,Koo S,Giori NJ

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of a brace intended to reduce load in patients with medial or lateral compartmental osteoarthritis (OA) and concurrent varus or valgus alignment, respectively. DESIGN:This multi-centre randomized controlled trial (performed 2001-2003) studies the additive effect of a brace intended to ...

journal_title：Osteoarthritis and cartilage

authors： Brouwer RW,van Raaij TM,Verhaar JA,Coene LN,Bierma-Zeinstra SM

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanical properties and morphological characteristics of articular cartilage on the tibial plateau of human knees, including the region covered by the meniscus. DESIGN:Using a 1-mm diameter flat-ended cylindrical probe to apply a constant load (0.6 MPa) at specific sites on the tibial pl...

journal_title：Osteoarthritis and cartilage

authors： Thambyah A,Nather A,Goh J

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:To describe the association between knee and hip radiographic osteoarthritis (ROA), a measure of knee pain, stiffness and functional ability and objectively measured physiological falls risk predictors. METHODS:Cross-sectional, population-based study of 850 randomly selected men and women aged 50-80 years (m...

journal_title：Osteoarthritis and cartilage

authors： Foley SJ,Lord SR,Srikanth V,Cooley H,Jones G

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Degeneration of articular cartilage leads to the development of osteoarthritis (OA), but the molecular pathology of the disease is poorly understood. The Disproportionate micromelia (Dmm) mouse has a deletion mutation in the C-propeptide encoding region of Col2a1, which leads to a defective cartilage matrix. ...

journal_title：Osteoarthritis and cartilage

authors： Bomsta BD,Bridgewater LC,Seegmiller RE

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Arthroscopic partial meniscectomy (APM) is the most frequently performed orthopedic procedure. Functional outcomes of APM are variable, particularly among patients with underlying knee osteoarthritis. While most patients undergoing APM have knee magnetic resonance imaging (MRI) performed preoperatively, the ...

journal_title：Osteoarthritis and cartilage

authors： Katz JN,Meredith DS,Lang P,Creel AH,Yoshioka H,Neumann G,Fossel AH,de Pablo P,Losina E

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Micro-computed tomography (microCT) imaging has the potential to allow the three-dimensional (3D) visualization of cartilage morphology. However, cartilage intensity on a microCT image is weak because cartilage does not strongly attenuate X-rays. This work was designed to demonstrate that exposure of cartilag...

journal_title：Osteoarthritis and cartilage

authors： Cockman MD,Blanton CA,Chmielewski PA,Dong L,Dufresne TE,Hookfin EB,Karb MJ,Liu S,Wehmeyer KR

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI) is a three-dimensional imaging technique with unparalleled ability to evaluate articular cartilage. This report reviews the current status of morphological assessment of cartilage with quantitative MRI (qMRI), and its relevance for identifying disease status, and monitoring pr...

journal_title：Osteoarthritis and cartilage

authors： Eckstein F,Cicuttini F,Raynauld JP,Waterton JC,Peterfy C

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:This study was performed to non-invasively visualize and characterize osteochondral (OC) repair in ex vivo goat stifles using an 8 T magnetic resonance imaging (MRI) scanner and to compare the MR morphology with images obtained from 1.5 T, gross morphology and histology. METHODS:Mature, neutered male goats w...

journal_title：Osteoarthritis and cartilage

authors： Kangarlu A,Gahunia HK

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Knee pain relief has been suggested to potentially alter radioanatomic positioning in conventional standing antero-posterior knee radiographs. This study was performed to determine whether this is always the case and in particular if it applied to two recent randomised, placebo-controlled trials showing both ...

journal_title：Osteoarthritis and cartilage

authors： Rovati LC,Pavelka K,Giacovelli G,Reginster JY

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Macromolecules of the articular cartilage extracellular matrix released into synovial fluid, blood, or urine can serve as potentially useful biomarkers of the severity of osteoarthritis (OA). Biomechanical factors play an important role in OA pathogenesis, yet their influence on biomarker production is not we...

journal_title：Osteoarthritis and cartilage

authors： Piscoya JL,Fermor B,Kraus VB,Stabler TV,Guilak F

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To investigate the biosynthetic response of elderly human femoral head articular cartilage to mechanical stimulation in vitro and its variation with site. METHOD:Full-depth cartilage biopsies of articular cartilage were removed from defined sites on 10 femoral heads from patients aged 68-95 years. Cartilage ...

journal_title：Osteoarthritis and cartilage

authors： Plumb MS,Aspden RM

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Substantial changes in articular cartilage composition and mechanical properties occur during the development of osteoarthritis (OA). While softening in the initial stage is reported and sometimes used as an indicator of early OA, there is a lack of data relating the macroscopic appearance of cartilage to its...

journal_title：Osteoarthritis and cartilage

authors： Kleemann RU,Krocker D,Cedraro A,Tuischer J,Duda GN

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Adipose tissue-derived mesenchymal stem cells (ATMSCs) have been shown to differentiate into bone, cartilage, fat or muscle. However, it is not certain that ATMSCs are equal to bone marrow-derived mesenchymal stem cells (BMMSC) for their bone and cartilage forming potential. The purpose of this study was to a...

journal_title：Osteoarthritis and cartilage

authors： Im GI,Shin YW,Lee KB

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. METHODS:Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled ...

journal_title：Osteoarthritis and cartilage

authors： Srikanth VK,Fryer JL,Zhai G,Winzenberg TM,Hosmer D,Jones G

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To devise a reliable, sensitive method to measure joint space in vivo during dynamic loading. Additionally, to determine if dynamic joint space changes were related to the severity of long-term cartilage damage. DESIGN:Subjects were 23 adult foxhounds (18 experimental, 5 control). Experimental subjects had s...

journal_title：Osteoarthritis and cartilage

authors： Anderst WJ,Les C,Tashman S

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To examine the effects of anterior cruciate ligament (ACL) insufficiency, and subsequent bisphosphonate (BP) antiresorptive therapy, on the bone mineral interface at the enthesis of remaining ligamentous restraints. METHODS:We measured bone mineral geometry (and subsequent adaptation) at the medial collatera...

journal_title：Osteoarthritis and cartilage

authors： Doschak MR,LaMothe JM,Cooper DM,Hallgrimsson B,Hanley DA,Bray RC,Zernicke RF

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:This study investigated the in vitro effects of hyaluronic acid (HA) of molecular weight (MW) 500-730 kDa on human articular chondrocytes cultivated for 48 h in the presence of interleukin-1beta (IL-1beta) with and without hydrostatic cyclical pressure. DESIGN:The effects of 10 and 100 microg/ml HA with and ...

journal_title：Osteoarthritis and cartilage

authors： Fioravanti A,Cantarini L,Chellini F,Manca D,Paccagnini E,Marcolongo R,Collodel G

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a degenerative disabling joint disease affecting more than 10% of the adult population. No validated disease-modifying treatment is available. Joint distraction is a relatively new approach to the treatment of severe ankle OA. Short-term (3 years) clinical benefit has been proven, but l...

journal_title：Osteoarthritis and cartilage

authors： Ploegmakers JJ,van Roermund PM,van Melkebeek J,Lammens J,Bijlsma JW,Lafeber FP,Marijnissen AC

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:To quantify tibial cancellous bone changes over 24 months in patients with medial compartment knee osteoarthritis (OA) subdivided into those with slow or detectable joint space narrowing (JSN). METHOD:Digitised macroradiographs (4x) were obtained at baseline and 24 months from 40 patients (F:26) and subdivid...

journal_title：Osteoarthritis and cartilage

authors： Messent EA,Ward RJ,Tonkin CJ,Buckland-Wright C

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to: 1. Evaluate the performance of arthroscopy for the diagnosis of chondropathy and to compare it to that of direct non-arthroscopic assessments; 2. Determine intra-observer reliability of arthroscopic assessments; 3. Evaluate the effects of the arthroscopic video quality and pro...

journal_title：Osteoarthritis and cartilage

authors： Oakley SP,Portek I,Szomor Z,Appleyard RC,Ghosh P,Kirkham BW,Murrell GA,Lassere MN

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism of aggrecanolysis in interleukin-1 (IL-1)-treated cartilage tissue by examining the time course of aggrecan cleavages and the tissue and medium content of membrane type 4-matrix metalloproteinases (MT4-MMP) and a disintegrin and metalloproteinase with thrombospondin type I motifs ...

journal_title：Osteoarthritis and cartilage

authors： Patwari P,Gao G,Lee JH,Grodzinsky AJ,Sandy JD

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:This study investigates the long-term changes of the periarticular bone, including cancellous bone and the subchondral plate, in an anterior cruciate ligament (ACL)-transected cat for post-traumatic osteoarthritis (OA). These periarticular bone changes are related to the health of all knee tissues including ...

journal_title：Osteoarthritis and cartilage

authors： Boyd SK,Müller R,Leonard T,Herzog W

更新日期：2005-03-01 00:00:00

abstract：:Variations among joints in the initiation and progression of degeneration may be explained, in part, by metabolic, biochemical and biomechanical differences. Compared to the cartilage in the knee joint, ankle cartilage has a higher content of proteoglycans and water, as well as an increased rate of proteoglycan turnov...

journal_title：Osteoarthritis and cartilage

authors： Kuettner KE,Cole AA

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN:Enzymatically isolated bovine chondrocytes were cultured for different periods in suspension in 21 (atmospheric), 5 or 1% (low) o...

journal_title：Osteoarthritis and cartilage

authors： Mathy-Hartert M,Burton S,Deby-Dupont G,Devel P,Reginster JY,Henrotin Y

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The effects of mechanical deformation of intact cartilage tissue on chondrocyte biosynthesis in situ have been well documented, but the mechanotransduction pathways that regulate such phenomena have not been elucidated completely. The goal of this study was to examine the effects of tissue deformation on the ...

journal_title：Osteoarthritis and cartilage

authors： Szafranski JD,Grodzinsky AJ,Burger E,Gaschen V,Hung HH,Hunziker EB

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Disturbances of the proteoglycan metabolism play an essential role in the pathology of osteoarthritis. The extracellular matrix proteoglycan, perlecan, has lately been identified as a cell biological factor in cartilage development and maintenance. We investigated the tissue distribution of perlecan, the rela...

journal_title：Osteoarthritis and cartilage

authors： Tesche F,Miosge N

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To determine the effects of interleukin (IL)-6 and oncostatin M (OSM) added separately or in combination with IL-1beta on human osteoarthritic (OA) chondrocytes in alginate beads. DESIGN:Human chondrocytes were isolated from OA cartilage and cultured in alginate beads for 12 days, in the absence or in the pr...

journal_title：Osteoarthritis and cartilage

authors： Sanchez C,Deberg MA,Burton S,Devel P,Reginster JY,Henrotin YE

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To compare the actions of fibroblast growth factor-basic (bFGF), insulin-like growth factor-I (IGF-I), platelet derived growth factor-AB (PDGF-AB), and transforming growth factor-beta 1 (TGF-beta1) on bovine meniscus tissue explants with and without static mechanical compression. DESIGN:Meniscus tissue expla...

journal_title：Osteoarthritis and cartilage

authors： Imler SM,Doshi AN,Levenston ME

更新日期：2004-09-01 00:00:00

abstract：INTRODUCTION:Articular cartilage matrix synthesis and degradation are dynamic processes that must be balanced for proper maintenance of the tissue. In osteoarthritis (OA), this balance is skewed toward degradation and ultimate loss of matrix. The transcriptional and/or activity levels of hundreds of genes are dysregula...

journal_title：Osteoarthritis and cartilage

authors： Arai M,Anderson D,Kurdi Y,Annis-Freeman B,Shields K,Collins-Racie LA,Corcoran C,DiBlasio-Smith E,Pittman DD,Dorner AJ,Morris E,LaVallie ER

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:In the current studies we have examined the effects of nitric oxide, and its redox derivatives peroxynitrite and S-nitrosothiol, S-nitrosocysteine, on nuclear factor kappaB (NF-kappaB) activation in cytokine-stimulated bovine chondrocytes. METHODS:The kinetics of NF-kappaB activation (p65 nuclear translocati...

journal_title：Osteoarthritis and cartilage

authors： Clancy RM,Gomez PF,Abramson SB

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to develop a specific immunoassay for PIIANP and measure its serum concentration in healthy controls and in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, we investigated circulating forms recognized by antiserum IIA in pools of serum from healthy adult...

journal_title：Osteoarthritis and cartilage

authors： Rousseau JC,Zhu Y,Miossec P,Vignon E,Sandell LJ,Garnero P,Delmas PD

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:To investigate the secretion profiles of matrix metalloproteinases (MMP) and their inhibitors (TIMP) in synovial fluid-derived fibroblasts and to compare them with those of tissue-derived fibroblasts. METHODS:Fibroblast cultures established from synovial tissues (TSC) and fluids (FSC) of the same OA patient...

journal_title：Osteoarthritis and cartilage

authors： Fuchs S,Skwara A,Bloch M,Dankbar B

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:To characterize the molecular events underlying cartilage injury in the early phase of mono-iodoacetate-induced osteoarthritis (OA) in rats. METHODS:Experimental osteoarthritis was induced by intra-articular injection of 0.03mg mono-iodoacetate (MIA) in Wistar rats. Animals were killed 2, 5, 10, 15 and 20 d...

journal_title：Osteoarthritis and cartilage

authors： Dumond H,Presle N,Pottie P,Pacquelet S,Terlain B,Netter P,Gepstein A,Livne E,Jouzeau JY

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN:Six experimental groups included norm...

journal_title：Osteoarthritis and cartilage

authors： Hulmes DJ,Marsden ME,Strachan RK,Harvey RE,McInnes N,Gardner DL

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To determine the response of immature articular cartilage to both sharp and blunt trauma in terms of cell death, cell proliferation and matrix synthesis. DESIGN:Blunt wounds were made with a trephine in full depth immature bovine articular cartilage explants which were cut in half through the center of the t...

journal_title：Osteoarthritis and cartilage

authors： Redman SN,Dowthwaite GP,Thomson BM,Archer CW

更新日期：2004-02-01 00:00:00